HFA-PEFF Score

ESC HFpEF Diagnostic Algorithm — 3 Domain Scoring System

Domain 1: Morphofunctional

Major criterion e′ septal < 7 cm/s OR e′ lateral < 10 cm/s OR average E/e′ ≥ 15 OR TR velocity > 2.8 m/s (SR) OR GLS < 16%

Minor criterion Average E/e′ 9–14 OR LAVI > 34 mL/m² (SR) OR LV wall thickness ≥ 12 mm OR LV mass index ≥ 115/95 g/m² (M/F) OR RWT > 0.42 OR E/e′ ≥ 13 (AF)

Not met

Domain 2: Biomarker

Major criterion NT-proBNP > 220 pg/mL (SR) OR > 660 pg/mL (AF) OR BNP > 80 pg/mL (SR) OR > 240 pg/mL (AF)

Minor criterion NT-proBNP 125–220 pg/mL (SR) OR 375–660 pg/mL (AF) OR BNP 35–80 pg/mL (SR) OR 105–240 pg/mL (AF)

Not met

Domain 3: Functional

Major criterion Exercise E/e′ ≥ 15 OR exercise PASP ≥ 60 mmHg OR PCWP rest ≥ 15 mmHg or exercise ≥ 25 mmHg

Minor criterion Average rest E/e′ 9–14 AND exercise E/e′ 10–14

Not met

Results

Morphofunctional Domain 0 / 2

Biomarker Domain 0 / 2

Functional Domain 0 / 2

Total HFA-PEFF Score 0

Score 0–1: HFpEF unlikely — consider alternative diagnoses

Reference

Pieske B et al. 2019 — How to diagnose heart failure with preserved ejection fraction: the HFA–PEFF diagnostic algorithm. Eur J Heart Fail.